Osteocalcin as a Gingival Crevicular Fluid Biomarker for Periodontitis among Egyptian Population Sample- Controlled Clinical Trial

Mohamed Al Bahrawy, Associate professor of Oral medicine and Periodontology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
Sahar Abdel Rauf, Lecturer of Oral medicine and Periodontology, Faculty of Dentistry, Misr International University, Cairo, Egypt
Eman M. Abdulhady, Lecturer of Oral medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Horus University, New Damietta City, EgyptFollow

Article Type

Original Article

Section/Category

Periodontology

Abstract

Objectives This clinical trial aimed to evaluate osteocalcin levels in healthy and diseased periodontium and to correlate the changes in its levels with the changes in the clinical and radiographic parameters before and after treatment. Subject & Methods Double blind clinical trial, 40 patients divided into 3 groups; 15 patients diagnosed as periodontitis stage III grade B, 15 patients diagnosed as periodontitis stage III grade C, 10 healthy cases as control. Clinical parameters namely plaque index (PI), gingival index (GI), periodontal pocket depth (PPD), clinical attachment loss (CAL), radiographic examination, beside gingival crevicular fluid (GCF) samples collection for osteocalcin (OC) level, tested at 2 time points 1 before (baseline) and 1 six months after periodontal treatment, which included phase I & II periodontal therapy accompanied by systemic antibiotics protocol. Results revealed a positive correlation in the changes of OC levels in GCF and periodontal clinical parameters including PI, GI, PPD, CAL and a negative correlation with the changes in bone density although these correlations were insignificant. Conclusions This study demonstrated that OC levels in GCF have remarkable difference between periodontally healthy and diseased groups. This would enhance the feasibility of using OC levels in GCF as a bone turn over biomarker for diagnosis and follow up of the periodontitis infection activity. Clinical relevance Osteocalcin would be suitable for diagnosis and follow up of the disease, but not suitable for the prognosis of periodontal disease infection.

Keywords

Bone marker - Osteocalcin - Periodontal disease

How to Cite This Article

Bahrawy M , Rauf S , Abdulhady E . Osteocalcin as a Gingival Crevicular Fluid Biomarker for Periodontitis among Egyptian Population Sample- Controlled Clinical Trial. Mans J Dent. 2024; 12(1):
Available at: https://doi.org/10.61793/2812-5479.1147