Anti–inflammatory effect of Angelica Shikokiana Makino leaves extract gel on lichen planus induced oral mucositis (Clinical Study).

Eman Shawki, Department of Oral medicine & Periodontology, Faculty of dentistry, Mansoura universityFollow

Corresponding Author

Eman Shawki

Article Type

Original Article

Abstract

Objective: to develop eco-friendly nanoemulsions of Angelica shikokiana natural extract gel and evaluate its anti-inflammatory activity by assessing the reduction of the present oral mucositis induced by oral lichen planus (OLP). Materials and Methods: Thirty-four patients with OLP participated in this randomized controlled trial, classified into two main groups. The first group ( study group) was given the prepared gel of Angelica shikokiana Makino (AS) leaves extract in orabase. The second group (control group) was given 0.1% triamcinolone acetonide (TA), known as kenacort in orabase. Clinical improvement was evaluated using the Thongprasom scale, and pain reduction was recorded using a numeric rating scale. Initial, midway, and final assessments were performed on the patients. Also, the serum level of interlukin 6 was evaluated at the baseline and the end of the study. Results: Statistical analysis showed that both groups' pain scores, overall lesion sizes, and Thongprasom scores improved with time. There was a statistically significant difference between week two and week four reports of improvement in the TA group and in AS group (P-value was≤0.05) indicating that the trend towards better health persisted through week 4. TA's analgesic impact was superior to Angelica shikokiana's during the second week, but by the fourth week, Angelica shikokiana had caught up to TA. At the end of the research period, both treatments significantly reduced lesion size (P-value≤0.005) in both groups There was a practical improvement in the oral mucositis associated with OLP in all patients after treatment with our gel. There was no significant difference between the serum level of interleukin six at the baseline and the end of the study (P-value 0.71825). Conclusion: Angelica shikokiana can be used as a treatment for OLP. It can be utilized as a backup plan in OLP when corticosteroids aren't working or when individuals decline therapy for fear of adverse effects.

Keywords

Lichen planus; Angelica shikokiana Makino, interlukin

How to Cite This Article

Shawki E . Anti–inflammatory effect of Angelica Shikokiana Makino leaves extract gel on lichen planus induced oral mucositis (Clinical Study).. Mans J Dent. 2023; 11(2): 85-90.
Available at: https://doi.org/10.61793/2812-5479.1117