Corresponding Author

Mona Mohsen Abdo Ibrahim

Article Type

Original Article


Objectives: To determine the nature of plasma cell proliferation in oral plasma cell granuloma either to be polyclonal or monoclonal via immunohistochemical expression of kappa(k) and lambda(λ ) antibodies. This study would confirm the diagnosis of oral plasma cell granuloma and exclude other plasma cell neoplasms.

Material and methods: This study was performed retrospectively on 25 oral plasma cell granuloma cases. Immunohistochemical expression of kappa and lambda light chains was made and the mean percentage of expression was scored semi-quantitatively. The ratio of kappa to lambda mean expression was recorded.

Results: All current study cases revealed positive cytoplasmic expression of both kappa and lambda antibodies in plasma cells. Moreover, the K: λ ratio equaled 2:1 in 44% of cases followed by 1:1 in 36% and 1:2 in the remaining 20% .This revealed a polyclonal nature of plasma cell proliferation. No statistically significant difference was observed in relation to the immunohistochemical expression of both antibodies and the clinical data (age ,sex &site) of the cases with p >.05.

Conclusion: Plasma cell granuloma of the oral cavity is a reactive lesion that might resemble plasmacytoma, a malignant plasma cell tumor that affects the oral soft tissue. Polyclonal expression of kappa and lambda light chains enables accurate diagnosis of oral plasma cell granuloma that requires conservative treatment with a favourable prognosis.


Plasma cell granuloma, polyclonal proliferation, plasmacytoma