Article Type

Original Article


Oral Medicine


Objective: To assess the effect of platelet-rich plasma (PRP) local injection in the treatment of periodontitis, as anadjunct to scaling and root planing (SRP).Materials and Methods: Ninety subjects were involved in this study. Theywere divided into 3 groups. Group I (negative control) included 30 subjects with healthy periodontium. Group II(positive control) included 30 periodontit is patients who were treated by SRP planing. Group III (study) included 30periodontitis patients who were treated with SRP and PRP injections. Plaque index (PI), Gingival index (GI), probingpocket depth (PPD), and clinical attachment level (CAL) in addition to MMP-8 level recorded at baseline for all groupsand 2 months post-treatment for groups II and III .Results: At baseline; PI, GI, PPD, CAL, and MMP-8 revealed nosignificant difference between group II and III (p > 0.05), while the periodontal parameters of both groups showed highlysignificant higher values versus group I (p < 0.001 for each). Both groups showed a highly significant decrease in PI, GI,PPD, and CAL after treatment (p < 0.001 for each). In addition, Group III showed significantly lower values in PI(P=0.028) and GI (p=0.032) and a highly significant decrease in PPD and CAL (p < 0.001 for each) versus Group II.However, after treatment, both groups II and III showed a highly significant decrease in MMP-8 (p < 0.001 and p=0.010respectively). No significant difference was found in the MMP-8 level between Group II and III as the mean±SD was1.73±0.58 and 1.9±0.49 respectively. Conclusions: Injection of autogenous PRP in addition to SRP in periodontalpockets can enhance clinical parameters of periodontitis.