Clinical Outcomes of Topical Phenytoin Loaded on Hydrogel Wound Dressing on Postoperative Sequalae Following Resection of Oral Squamous Cell Carcinoma

Abdelrahman Mohammed Yehia Abdellatif, Demonstrator of Oral and Maxillofacial surgery, Faculty of Dentistry, Mansoura University, Egypt.Follow
Mohamed Zaghloul Amer, Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Egypt.
Shadi Awny, Associate professor of surgical oncology, Faculty of Medicine, Mansoura University, Egypt
Mohammed AbdeL-monem Tawfik, Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Egypt.

Article Type

Original Article

Section/Category

Oral and Maxillofacial Surgery

Abstract

Objective: This study aimed to assess the clinical outcomes of topical phenytoin loaded on hydrogel wound dressing on postoperative sequalae following resection of oral squamous cell carcinoma.

Material and Methods: Sixteen patients were selected from the Outpatient Clinic of the oncology center, Mansoura University complain of oral squamous cell carcinoma require major surgery for resection, neck dissection with further reconstruction. Patients were equally categorized into two groups. In study group, eight patients received a phenytoin-based hydrogel wound dressing following resection and reconstruction procedure. While in control group, including eight patients received a conventional wound dressing following resection and reconstruction procedure.

Results: A statistically significant difference was observed between the study and control groups. in wound healing at two weeks postoperative. The postoperative pain and discomfort decreased in study group, particularly in one week. However, no statistically significant difference was observed between the groups regarding postoperative complications or mucositis at any of the evaluated time points. Nevertheless, intragroup analysis showed statistically significant changes within each group over time.

Conclusion: Phenytoin loaded on hydrogel demonstrated significant outcomes in enhancing wound healing and reducing pain and discomfort following resection of oral squamous cell carcinoma. Further research involving different types of oral wounds is recommended to better define its potential role in the future management of oral wound healing.

Keywords

Phenytoin, Hydrogel, Squamous cell carcinoma, Wound healing

How to Cite This Article

Yehia Abdellatif A , Amer M , Awny S , Tawfik M . Clinical Outcomes of Topical Phenytoin Loaded on Hydrogel Wound Dressing on Postoperative Sequalae Following Resection of Oral Squamous Cell Carcinoma. Mans J Dent. 2026; 13(3):
Available at: https://doi.org/10.61793/2812-5479.1195